Fc mediated function assays (ADCC, ADCP)

Antibody‑dependent cellular cytotoxicity (ADCC) and antibody‑dependent cellular phagocytosis (ADCP) assays are widely applied to evaluate Fc‑mediated antibody functions against a range of viral and bacterial pathogens for which non‑neutralizing antibody mechanisms contribute to protection.

ADCC assay measures the ability of therapeutic antibodies to guide immune cells (like NK cells) to kill target cells. It is crucial for assessing antibody efficacy, with common methods including flow cytometry for direct cell killing or luminescence-based assays.

Compared with conventional binding serology, ADCC and ADCP assays provide functional insight into Fc‑effector mechanisms that are not captured by neutralization or ELISA‑based assays and may represent critical components of protective immunity. As such, these assays are increasingly incorporated into vaccine immunogenicity assessments and advanced immune profiling to support a comprehensive evaluation of antibody quality and mechanism of action.

VisMederi specializes in ADCC and ADCP assays for the evaluation of influenza vaccine-induced immune responses. Leveraging this expertise, the company can adapt and implement these functional assays for other viral and bacterial targets, supporting the development of vaccines and immunotherapies across multiple disease areas.